![]() 4 The current challenges in managing paracetamol toxicity include the changing profile of paracetamol toxicity with “massive” and modified release ingestions and providing a more tailored approached to acetylcysteine therapy. 3 There are increasing cases of poisoning and liver injury, with increasing availability of paracetamol, including modified release formulations. 1, 2 In 2018, the American Association of Poison Control Centres provided approximately 2.1 million tele-consults for the United States and associated territories, of these over 100 000 calls related to paracetamol exposure. Paracetamol toxicity is a major problem in Western countries, and acute overdose remains the commonest cause of acute liver failure in Europe, North America and Australia.
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